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Topiramate modulates recombinant GABA(A) receptors by a nonbenzodiazepine mechanism

N Müller, K Krampfl, J Bufler · Aktuelle Neurologie · 2004 · Heft 09

Dokument
1039181
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
N Müller, K Krampfl, J Bufler
Ausgabe
Heft 09 / 2004
Seiten
–
Erschienen: 2004-09-07 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2004-833115

Zusammenfassung

Purpose: The study investigates the mechanism of action of topiramate at recombinant GABA(A) receptor subtypes. Methods: HEK293 cells were transiently transfected with cDNAs of different GABA(A) receptor subunits. Alpha1beta2gamma2, alpha6beta2gamma2, alpha6beta2delta, and alpha6beta2 GABA(A) receptor subtypes were functionally expressed in HEK293 cells. Topiramate enhancement of GABA (1–10 microM)-evoked currents was studied by using whole-cell electrophysiologic techniques while modulation of currents evoked by saturating GABA concentrations was studied using outside-out patches excised from transfected cells.…

Schlagworte

Benzodiazepine Aktuelle Neurologie