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Possible shared genetic risk factors for Gilles de la Tourette syndrome and obsessive compulsive behaviour: the Val66Met polymorphism of the brain derived neurotrophic factor (BDN…

S Klaffke, IR König, F Poustka, A Ziegler, J Hebebrandt, O Bandmann · Aktuelle Neurologie · 2004 · Heft 09

Dokument
1039200
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
S Klaffke, IR König, F Poustka, A Ziegler, J Hebebrandt, O Bandmann
Ausgabe
Heft 09 / 2004
Seiten
–
Erschienen: 2004-09-07 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2004-833305

Zusammenfassung

Objective: To evaluate a possible association of the Valine66Methionine (Val66Met) polymorphism of the brain-derived neurotrophic factor (BDNF) gene [MIM113505] with Gilles de la Tourette syndrome (GTS) by genotyping the single nucleotide polymorphism (SNP) for the G->A polymorphism at position 758 of the BDNF coding sequence in 88 GTS trios. Background: BDNF is a member of the neurotrophin superfamily promoting cell survival and neuronal differentiation. A significant association of the Val66Met polymorphism of BDNF in patients with childhood-onset obsessive-compulsive disorder (OCD) was recently described. In…

Schlagworte

Allele Association Adolescent Population Alleles Germany Aktuelle Neurologie