The role of Rho-family GTPases in human glioblastomas

Introduction: GTPases of the Rho-family act as molecular switches cycling between an inactive GDP-bound and an active GTP bound state. Beside cell cycle control, cell-cell and cell-matrix interaction Rho-GTPases are involved in the organisation of the cytoskeleton in response to extracellular stimuli. Oncogenic features like cell migration and invasion are a function of the actin cytoskeleton and characteristic of human glioblastomas. As the molecular mechanisms of migration of glioblastomas are poorly understood we investigated the expression of Rho-GTPases in human glioblastomas. Materials and Methods: mRNA of…