CareLit Fachartikel

Mechanisms of excitotoxicity: AMPA-mediated calcium dynamics in spinal motoneurons

M Jaeckel, K Haastert, P Claus, C Grothe, R Dengler, J Bufler, J Grosskreutz · Aktuelle Neurologie · 2004 · Heft 09

Dokument
1039206
CareLit-ID
Jahr
2004
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
M Jaeckel, K Haastert, P Claus, C Grothe, R Dengler, J Bufler, J Grosskreutz
Ausgabe
Heft 09 / 2004
Seiten
–
Erschienen: 2004-09-07 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2004-833365

Zusammenfassung

Introduction: ALS is a neurodegenerative disease, which is characterized by rapid loss of motoneurons. Chronic AMPA- receptor mediated excitotoxicity seems to play a major role in the pathogenetic process, but the mechanisms of the selective vulnerability of motoneurons are still unknown. Apoptosis like degeneration of motoneurons after excitotoxic insults can be imitated in vitro, proposing extensive mitochondrial calcium uptake, increased production of reactive oxygen species and delayed collaps of calcium homeostasis as mechanisms involved. Methods: Ventral spinal chord was prepared from 14- day- old rat embr…

Schlagworte

Calcium AMPA After Dantrolene Reactive Oxygen Species Apoptosis Aktuelle Neurologie