Beta-catenin and eta-cadherin are differentially expressed in motor and sensory spinal nerves during early postnatal myelination in the PNS
P Young, K John, H Halfter · Aktuelle Neurologie · 2004 · Heft 09
Bibliografische Angaben
Zusammenfassung
Beta-catenin, the main intracellular binding molecule for classical cadherins and its extracellular binding partner eta-cadherin are expressed in uncompacted myelin compartments of the mature peripheral nervous system (PNS) like the paranodal regions of the nodes of Ranvier (NOR) and Schmidt-Lanterman incisures (SLI). Very recently it was shown that beta-catenin is essential for differentiation of neuronal stem cells towards sensory dorsal root neurons during embryonal development. To what extend the cadherin-catenin complex is involved in proper function of Schwann cells (SC) and axons during myelination and or…