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Beta-catenin and eta-cadherin are differentially expressed in motor and sensory spinal nerves during early postnatal myelination in the PNS

P Young, K John, H Halfter · Aktuelle Neurologie · 2004 · Heft 09

Dokument
1039207
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Zeitschrift
Aktuelle Neurologie
Autor:innen
P Young, K John, H Halfter
Ausgabe
Heft 09 / 2004
Seiten
–
Erschienen: 2004-09-07 00:00:00
ISSN
0302-4350

Zusammenfassung

Beta-catenin, the main intracellular binding molecule for classical cadherins and its extracellular binding partner eta-cadherin are expressed in uncompacted myelin compartments of the mature peripheral nervous system (PNS) like the paranodal regions of the nodes of Ranvier (NOR) and Schmidt-Lanterman incisures (SLI). Very recently it was shown that beta-catenin is essential for differentiation of neuronal stem cells towards sensory dorsal root neurons during embryonal development. To what extend the cadherin-catenin complex is involved in proper function of Schwann cells (SC) and axons during myelination and or…

Schlagworte

Beta-Catenin beta Catenin Axons Demyelinating Diseases Cadherins Aktuelle Neurologie