Secretory Leukocyte Protease Inhibitor Protein (SLPI) is an Novel Early Induced Gene in the Rat Liver Regeneration

Liver regeneration has been extensively studied but its molecular mechanism is still poorly understood. We applied the model of 70% partial hepatectomy (PH) to study liver regeneration in the rat by adult hepatocytes proliferation. Serial Analysis of Gene Expression (SAGE) was employed to study the gene expression profile at an early stage of regeneration (8 hours after PH). In addition, RNA extracted from livers of sham operated and normal animals was analysed by the same technique. Comparison of the three different transcriptomes identified genes differentially regulated in the regeneration process: 38 genes w…