Monocyte chemoattractant protein MCP-1 gene polymorphism in Sarcoidosis

Background: Monocyte chemoattractant protein (MCP)-1 is expressed by monocytes and human pulmonary type-2 epithelial cells and many others. This CC chemokine exhibits chemotactic activity towards macrophages/ monocytes and induces the production of inflammatory cytokines affecting granuloma formation, which is of interest in sarcoidosis. Recently, a biallelic A/ G polymorphism has been found in the distal regulatory region of the MCP-1 gene at position – 2518 that affects the level of MCP-1 expression in response to an inflammatory stimulus. We investigated the influence of the MCP-1 (-2518) polymorphism on susc…