Reversal of pulmonary vascular remodeling induced by hypoxia in mice by the soluble guanylate cyclase activator Bay 58–2667

Severe pulmonary hypertension is a disabling disease with high mortality. We investigated the effects of the soluble guanylate cyclase activator Bay 58–2667 on hemodynamics and vascular remodeling in hypoxia-induced pulmonary hypertension in mice. Twenty-one and 35 days after chronic hypoxia (10 % O2), right ventricular systolic pressure (RVSP) increased from 22,4±2,0 to 38,9±3,8 and 44,3±5,2mm Hg, respectively. Marked right heart hypertrophy was demonstrated by the strongly elevated ratio of right ventricle/left ventricle plus septum weight and thickening of the precapillary artery smooth muscle layer. When chr…