Protection against trinitrobenzene sulphonic acid-provoked colonic inflammation by endogenous oestrogens

Ulcerative colitis and Crohn's disease are both inflammatory bowel diseases. It has been shown that vascular infarctions play a role in the etiology of the severe transmural inflammation, characteristic of Crohn's disease. On the other hand, there is growing evidence that endogenous oestrogen is involved in the physiologic regulation of the vasodilator vascular tone. For the investigation of the mechanism of Crohn's disease, colonic injury following the local administration of 2,4,6-trinitrobenzene sulphonic acid (TNBS) is generally used. Aim: We compared TNBS-induced colonic injury in male, female and ovariecto…