The change of motility compared with the gastric-acid secretion after atropine administration in rats

The vagal nerve has important role in the regulation of gastric acid secretion and motility. It was not known how the parts of gastric function are influenced by the effects of cholinergic innervation. Early study proved that the ED50 value in inhibition of gastric acid secretion of atropine is 1.78µmol/kg (-log: 5.75)(Mózsik and Jávor. Dig. Dis. Sci. 1988;33:92–105). The aims of study were to determinate the ED50 value of atropine in relation the decrease of gastric emptying and to compare the both ED50 levels. Materials and methods: The observation was carried out on Sprague-Dawley rats weighing 210–230g of bo…