Role of adrenergic system in centrally induced gastroprotection of opioids

Background: Our previous experiments showed that vagotomy decreased the gastroprotective effect of intracerebroventricularly (icv.) administered opioid peptides, suggesting the essential role of the vagal nerve in these protective processes. However, the inhibition was not complete, indicating possible role of other mechanisms. Our present experimental series aimed to examine the potential role of the adrenergic system in opioid-induced gastroprotection. Methods: After 24 hour starvation male Wistar rats were given acidified ethanol orally. Gastric lesions were evaluated 1 hour later. Opioids were given icv. 10…