Severe lactic acidosis caused by sodium nitroprusside in a newborn with congenital heart disease

Objective: Sodium nitroprusside (SNP) is an antihypertensive drug used frequently in the critical care setting. Coadminstration of the antidote sodium thiosulfate usually prevents increases in cyanide concentrations during anesthesia or long-term SNP infusion (1). We report on a newborn with congenital heart disease who developed severe lactic acidosis due to the administration of SNP despite concomitant medication with sodium thiosulfate. Case report: A 3800g-female newborn was admitted to our hospital because of complex congenital heart disease (double inlet left ventricle, dysplasia of the right ventricle, at…