Bladder dysfunction in IPD and atypical Parkinsonian disorders – pathophysiology and treatment

Lower urinary tract symptoms (LUTS) in Parkinson's disease (PD) and atypical Parkinsonian disorders (APD) are common, and animal studies have suggested that dopaminergic mechanisms may play a significant role in LUTS in PD, whereas mechanisms in APD are poorly understood. We present data regarding the prevalence of LUTS in PD and the role of dopaminergic degeneration in the striatum. 107 patients with PD were interviewed using 2 sets of questionnaires regarding LUTS, severity of disease was assed by the modified Hoehn & Yahr rating scale, and volumes of postmicturitional urine (PMV) were measured. Scores related…