Combination of surgical resection and interstitial radiosurgery as a treatment concept for WHO grade II glioma in complex localisation

Objective: The current prospectively designed pilot study analyzed the feasibility and outcome of a combined microsurgical / interstitial radiosurgical approach for patients with highly eloquently located supratentorial WHO Grade II glioma. Methods: Between 1998 and 2005 36 patients fulfilled the study protocol: Tumor resection was performed as radically as possible in every patient using multimodal intraoperative stimulation techniques; Interstitial radiosurgery (IRS) was done in remaining or recurrent circumscribed tumors with a diameter