Altered Response of Peripheral Blood Mononuclear Cells to Substance P Stimulation in Patients with Irritable Bowel Syndrome;

Aims: Transient infections are known to alter visceral sensory function and precipitating the onset of symptoms in patients with irritable bowel syndrome (IBS). Substance P (SP) plays a central role in the interaction of immune cells and visceral afferents mediated via G-protein coupled receptors. A G-protein (GNB3) polymorphism (CC-genotype) is known to be a risk factor for functional gastrointestinal disorders. Thus we aimed (1) to characterize the effect of the pro-inflammatory neuropeptide SP on proliferation and (2) Neurokinin 1 receptor (NK1R) expression of peripheral blood mononuclear cells (PBMC) in IBS…