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Interim results from the PACT-trial: High antiviral efficacy of daily consensus interferon/ribavirin compared to peg-interferon alfa2b/ribavirin in treatment-naive patients with c…

WO Böcher, M Fuchs, P Buggisch, S Kaiser, R Link, J Nalop, C Antoni, J Schlaak, T Witthöft, PR Galle, HF Löhr · Zeitschrift für Gastroenterologie · 2006 · Heft 04

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1040347
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Jahr
2006
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
WO Böcher, M Fuchs, P Buggisch, S Kaiser, R Link, J Nalop, C Antoni, J Schlaak, T Witthöft, PR Galle, HF Löhr
Ausgabe
Heft 04 / 2006
Seiten
–
Erschienen: 2006-04-10 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2005-920035

Zusammenfassung

Introduction: Consensus interferon (CIFN) is a synthetic type 1 interferon with enhanced in vitro activity compared to conventional IFN-alfa (IFNa). In the prospective, randomized multicenter PegIntron-Against-Consensus-Trial (PACT), the efficacy and safety of daily CIFN-treatment and ribavirin is compared to peg-IFNa2b plus ribavrin. Methods: 400 patients with chronic HCV infection and serotype–2 or –3 will randomly be assigned to treatment with 9 mcg qd CIFN sc. (group A) or peg- IFNa2b (1,5 mcg/kg body weight once weekly, group B), each in combination with ribavirin (>10,6mg/kg body weight) for 24 weeks. Trea…

Schlagworte

Zeitschrift für Gastroenterologie