Prognostic Utility of a Gene-Expression Signature in Untreated Node-Negative Breast Cancer
M Schmidt, D Böhm, C Glawatz, A Victor, M Gehrmann, CM Messow, E Steiner, M Munnes, HA Lehr, H Kölbl · Zentralblatt für Gynäkologie · 2005 · Heft 10
Bibliografische Angaben
Zusammenfassung
Purpose: Gene expression profiling has the potential to lead to a more accurate prognostic classification of breast cancer patients. Recently, a set of 70 genes had been identified that allowed risk classification of node-negative patients. We analysed the prognostic utility of a subset of these genes and compared it with established prognostic factors in a collective of 150 untreated node-negative breast cancer patients. Methods: cRNA of 150 untreated node-negative breast cancer patients was hybridized on the Affymetrix HG-U133A array and probe sets corresponding to the set of 70 genes were identified. A good a…
