Influence of acute and chronic energy balance changes on circulating concentrations of human peptide YY

Low human peptide YY (PYY) plasma levels were recently reported to justify PYY replacement therapy in human obesity (N Engl J Med 2003 349(10) 941–948). The pharmacological potential of PYY 3–36 (mainly circulating form of PYY) is discussed controversially, as the influence of PYY in the regulation of energy balance remains unclear. Methods: PYY plasma levels of 51 lean (BMI: 22.7±0.5kg/m2), 20 anorectic (BMI: 15.2±0.2), 53 obese (BMI: 33.2±0.7) and 13 morbidly obese (BMI: 43.2±2.1) subjects were investigated. Additionally PYY levels from 13 obese patients before and after weight loss (-4.2%) and 20 anorectic pa…