Flt3L elicited lung dendritic cells are recruited via β2 integrin dependent pathways and amplify the lung inflammatory response to LPS

Background: Dendritic cells (DCs) are critical to immunosurveillance of the lung. However, little is known about the recruitment pathways that mediate DC trafficking towards the lung under baseline and acute inflammatory conditions. Likewise, it is unclear whether recruited DCs beside their known function as antigen-presenting cells further contribute to acute lung inflammation. Methods: Recruitment pathways of DCs trafficking towards the lungs under baseline versus acute lung inflammatory conditions were assessed in C57BL/6 mice pretreated for 9 consecutive days with the DC-specific hematopoietic growth factor,…