Gadofluorine M-enhanced MR neurography visualizes focal nerve lesions in experimental demyelination

Magnetic resonance imaging (MRI) has become increasingly important in the diagnosis of neuromuscular disorders. Recently, we have shown that the novel micellar magnetic resonance (MR) contrast agent gadofluorine M (Gf) visualizes Wallerian degeneration after crush injury and inflammatory nerve lesions in experimental autoimmune neuritis (EAN) in rats. In comparison to complete axonal lesions, in which Gf enhancement of the lesion site and the distal aspect of the nerve is seen, Gf enhancement after experimental demyelination was studied in rats. Focal demyelination was induced by injection of lysolecithin into t…