The effects of trypsin on pancreatic ductal epithelia
I Ignáth, V Venglovecz, B Ózsvári, Z Ifj Rakonczay, T Takács, J Lonovics, K Borka, Z Schaff, A Tóth, A Varró, M Sahin-Tóth, P Hegyi · Zeitschrift für Gastroenterologie · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Background: The pathophysiology of acute pancreatitis is associated with pancreatic hypersecretion in the early stages of the disease. Under these conditions, premature activation of trypsinogen has been described in acinar cells, which can activate protease-activated receptor-2 (PAR-2) and trigger cellular responses. However, no data is available on the localization and activation of PAR-2 in pancreatic duct cells. The aim of this study was to investigate the expression of PAR-2 and the effects of trypsin and PAR-2-activating peptide (PAR2-AP) on intracellular Ca2+ levels of guinea pig pancreatic duct cells. Me…
