DLG5 R30Q is not associated with IBD in Hungarian patients, but predicts clinical response to steroids in Crohn's disease
PL Lakatos, S Fischer, K Claes, L Lakatos, A Kovacs, T Molnár, I Altorjay, P Demeter, K Palatka, M Papp, Z Tulassay, F Szalay, S Vermeire, J Papp · Zeitschrift für Gastroenterologie · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Aim: Recent data have suggested that specific haplotypic variants of the DLG5 gene on chromosome 10q23 may be associated with susceptibility to inflammatory bowel disease (IBD) in Germany. In view of the geographical differences in frequency of genetic markers and absence of data in Central-European patients, our aim was to determine the DLG5 R30Q in Hungarian IBD patients. Methods: 773 unrelated IBD patients (age 38.1±10.3 years, duration 8.8±7.5) years), CD: 639 and UC: 134) and 150 healthy subjects were investigated. DLG R30Q was tested by PCR-RFLP. Detailed clinical phenotype was determined by review of the…
