Endoscopic full-thickness plication for the treatment of GERD: a randomized, sham-controlled trial
K Caca, C Filipi, R Pruitt, K Mergener, A Torquati, G Haber, Y Chen, K Chang, D Wong, J Deviere, D Pleskow, C Lightdale, A Ades, R Kozarek, W Richards, A Lembo, R Rothstein · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background & aims: The aim of this study was to determine the effectiveness of endoscopic full-thickness plication (Plicator; NDO Surgical, Inc., Mansfield, MA) for the treatment of GERD in comparison to a sham procedure. Methods: Patients with symptomatic GERD requiring maintenance proton pump inhibitor therapy were entered into a randomized, single-blind, prospective, multicenter trial. Seventy-eight patients were randomly assigned to undergo endoscopic full-thickness restructuring of the gastric cardia with transmural suture. Eighty-one patients underwent a sham procedure. Group assignments were revealed foll…