IL-23 cross-regulates IL-12 production in T cell dependent experimental colitis
C Becker, H Dornhoff, C Neufert, M Fantini, S Wirtz, S Hübner, A Nikolaev, HA Lehr, AJ Murphy, DM Valenzuela, GD Yancopoulus, PR Galle, M Karow, MF Neurath · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
IL-12 is a key regulatory cytokine in cell-mediated immunity and induces the differentiation of naïve T cells towards a TH1 phenotype. The pathogenic activity of IL-12 has been demonstrated in various TH1-mediated experimental models of autoimmune diseases including inflammatory bowel disease (IBD). Moreover, a recent clinical trial showed that targeting of the p40 subunit of IL-12 by neutralizing antibodies suppresses gut inflammation in patients with Crohn's disease. However, since the recently discovered IL-23 shares the p40 subunit with IL-12, the role of IL-12 may have been overestimated in studies using ne…
