Anion transport pathways involved in PG E2 and acid-stimulated murine duodenal bicarbonate secretion in vivo

Aims: Duodenal HCO3- secretion is an important factor in epithelial protection, and mediated by the CFTR anion channel, as well as one or several anion exchangers of the SLC26 family. It is stimulated by contact of the epithelium with acid. This acid-induced stimulation is largely mediated via the release of endogenous prostaglandins. Recently, we found that duodenal mucosa in vitro of mice lacking the anion exchanger PAT1 (Slc26a6) displays a mild reduction in basal, and a severe reduction in PG E2-stimulated HCO3- secretion (Gastroenterology 2006;130:349–58). Aim: To determine whether PAT1 is involved in acid-…