Irinotecan/capecitabine versus cisplatin/capecitabine in advanced adenocarcinoma of the stomach or gastroesophageal junction: Interimsanalysis of a randomized German AIO phase II…

Aims: Irinotecan in combination with 5-FU is highly effective in advanced or metastatic gastric cancer. In addition, capecitabine seems to be at least as effective as 5-FU, with its advantage of oral administration. Thus, we compared efficacy and toxicity of the combinations of irinotecan/capecitabine versus cisplatin/capecitabine. Methods: Patients (pts) with previously untreated locally advanced or metastatic adenocarcinoma of stomach or gastroesophageal junction, and a Karnofsky Performance status (KPS) of at least 60%, at least one measurable lesion and adequate organ functions were eligible. Pts were random…