Inhibition of tumor growth of cervical cancer cell line in a murine xenograft model by thalidomide

Aims: Up to one fourth to 50% of primary, local advanced and/or recurrent cercinoma of the cervix uteri might fail to further treatment after no response of previous therapy. Several cytokines (like TNF, IL-2 and others), alterations of adhesion molecules and neoangiogenesis are involved in tumor progression. Recent research has shown the antineoplastic effect of thalidomide (TD) Here, we have studied the effect of TD on a cervical cancer cell line in a murine xenograft model. Methods: Cervical cancer tumor cells were into the dorsal skin of 6–8 week-old male nude mice (cd nu-/nu-; Charles River, Sulzfeld, Germa…