Evaluation of functional gene polymorphisms in the FSH receptor of patients with Ovarian Hyperstimulation Syndrome (OHSS)

OHSS most often occurs as a complication of ovarian stimulation treatments for in vitro fertilization (IVF) and is accompanied with increased polycystic ovaries, edemas and ascites. The incidence of OHSS ranges from 0.6–14%, with severe OHSS cases ranging from 0.2–5%. The clinical manifestations vary from abdominal distension to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Follicle-stimulating hormone (FSH) acts through membrane-associated cell receptors (FSHR) to stimulate granulosa cell proliferation and differentiation and is necessary for the proper f…