Role of the novel PAI-1 RNA Binding Protein in Epithelial Ovarian Cancer

Aims: The plasminogen activator-plasmin cascade plays a central role in tumor cell invasion and metastasis of solid tumors. The type-1 plasminogen activator inhibitor (PAI-1) is the major physiologic regulator of the plasminogen activation. The novel PAI-RBP1 is suggested to play a crucial role in cyclic nucleotide-mediated regulation of PAI-1 mRNA stability. The expression of PAI-RBP1 in ovarian cancer (OC) is unknown. We are the first working group to analyse the expression of the novel Plasminogen Activator Inhibitor type 1 mRNA Binding Protein (PAI-RBP1) in OC. Methods: Identification of overexpressed genes…