Polar body diagnosis: A highly reliable tool to diagnose age related aneuploidies

Introduction: In humans, aneuploidy rates determined in newborns are clearly related to maternal age. Assisted reproductive treatment (ART) now allows to study age related aneuploidy rates of fertilised oocytes by polar body diagnosis (PBD) through fluorescence-in-situ-hybridisation (FISH). Materials and methods: PBD using the MultiVysion™ PB multicolor probe panel (Abbott) specific for chromosomes 13, 16, 18, 21 and 22 was performed on the first and second polar bodies of 760 fertilised oocytes from 209 ART cycles. The study population included 172 women with an average age of 36.8 years (±4.6; range of 20.9–46…