CareLit Fachartikel

Prognostic significance of inhibin/activin subunits (alpha, betaA and betaB) and steroid receptors (ER and PR) in human endometrial carcinoma

I Mylonas, S Worbs, N Shabani, D Dian, D Mayr, C Kuhn, S Kunze, S Schulze, H Sommer, U Jeschke, K Friese · Geburtshilfe und Frauenheilkunde · 2006 · Heft 09

Dokument
1041356
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Jahr
2006
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
I Mylonas, S Worbs, N Shabani, D Dian, D Mayr, C Kuhn, S Kunze, S Schulze, H Sommer, U Jeschke, K Friese
Ausgabe
Heft 09 / 2006
Seiten
–
Erschienen: 2006-09-19 00:00:00
ISSN
0016-5751
DOI
10.1055/s-2006-952515

Zusammenfassung

Introduction: Inhibins (INH) are dimeric glycoproteins, composed of an alpha-subunit (INH-a) and one of two possible beta-subunits (INH-bA or -bB), with substantial roles in human reproduction and in endocrine-responsive tumours. Aims of this study were to examine the expression of INH-a, -bA and -bB as well as steroid receptors (ER and PR) and evaluated their clinical significance in endometrial carcinomas. Materials and Methods: 288 endometrial carcinoma cases were examined using immunohistochemistry with archival specimens. The findings were correlated with various clinicopathologic variables, including WHO g…

Schlagworte

Geburtshilfe und Frauenheilkunde