Feasibility, toxicity and quality of life of 1st line chemotherapy with platinum/paclitaxel under phase III clinical trial conditions in elderly patients aged ≥ 70 years with adva…
F Hilpert, A duBois, E Greimel, J Hedderich, G Krause, L Venhoff, J Pfisterer · Geburtshilfe und Frauenheilkunde · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Today, there is evidence that despite several improvements of general health care and supportive therapies, elderly patients with advanced ovarian cancer are still not treated with the currently recommended standard carboplatin/paclitaxel. This study evaluates first-line platinum/paclitaxel under phase III trial conditions in ovarian cancer (OC) patients aged ≥ 70 years. Methods: Phase III results of 779 patients with OC FIGO stage IIB/IV treated with cisplatin/paclitaxel versus carboplatin/paclitaxel were retrospectively analyzed according to feasibility, toxicity (NCI-CTC) and quality of life (Qol) (EORT…