C-11methionine positron emission tomography in recurrent gliomas

Objective: In this study we investigate the malignant progression of recurrent gliomas using C11 Methionine Positron Emission Tomography (PET). Methods: Seventeen Patients with histologically proven glioma were investigated repeatedly with C11-methionine PET. In total 40 C11-methionine PET scans were done. Each patient underwent follow-up C11-methionine PET investigation before open surgery or stereotactic biopsy. Results: During the study 13 patients had histologically proven progression of tumor grade (in two cases in two steps from grade II to grade III and later to grade IV). Four patients demonstrated no ch…