In vivo voxel-based morphometry in myotonic dystrophy type 2

Introduction: Myotonic dystrophy type 2 (DM2), is a distinct neuromuscular disorder with multisystemic involvement. Although cognitive impairment and white matter lesions are more common in patients with myotonic dystrophy type 1 (DM1), white matter lesions and a reduction of the brain volume have been described in DM2 as well. In this study, we used voxel-based morphometry (VBM) to study the morphology of the DM2-affected brain in vivo. Methods: We compared 13 DM2-patients (5 women, 8 men, age 53.35±11.96 years (y), disease duration 12.04±8.79 y) with 13 age- and sex-matched healthy controls (5 women, 8 men, ag…