ARUBA – A Randomized Trial of Unruptured Brain AVMs

Rationale: Current invasive treatment for brain arteriovenous malformations (AVMs) is varied and includes endovascular procedures, neurosurgery, and radiotherapy alone and in combination, largely dependent on the decisions of the local clinical team. However, no controlled treatment data on invasive AVM therapy exist and recent data raise serious doubt about the treatment benefit for unruptured brain AVMs. We propose a randomized treatment trial testing the hypothesis that medical management improves long-term outcomes of patients with unruptured AVMs compared to invasive treatment. Design: ARUBA is an internati…