Efficacy and safety of the special Extract Rheum rhaponticum (ERr 731®) in perimenopausal women with climacteric complaints

Perimenopause is the time until the last menstruation, when women experience irregular menstruation and climacteric symptoms. Due to an increased risk of breast cancer with hormone therapy in this phase, alternative treatments for climacteric complaints are highly desirable. A special extract from the roots of Rheumrhaponticum, referred to as ERr 731® (Phytoestrol® N), has been prescribed for climacteric complaints since 1993. It consists of rhaponticin, desoxyrhaponticin and their aglycones rhapontigenin and desoxyrhapontigenin, being structurally related to resveratrol. Objective To evaluate the efficacy and s…