CareLit Fachartikel
Pentacyclic triterpenoids from Boswellia serrata inhibit NFκB activation and TNF-α release. Implications for the treatment of chronic inflammatory diseases
T Syrovets, Y Laumonnier, B Büchele, T Simmet · Zeitschrift für Phytotherapie · 2006 · Heft 11
Dokument
1041521
CareLit-ID
Jahr
2006
Publikation
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Metadaten
DOI
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Zusammenfassung
In traditional Ayurvedic medicine extracts from the oleogum resin from Boswellia serrata have been used for the treatment of various chronic inflammatory diseases. Such extracts have been successfully employed in clinical pilot studies for the treatment of ulcerative colitis and rheumatoid arthritis. We have isolated and characterized various acetyl-boswellic acids (ABA), which constitute the active principle of Boswellia serrata extracts. Proinflammatory cytokines such as tumor necrosis factor (TNF)-α are prevalent at the sites of chronic inflammation, where they are critically involved in the chronification pr…
Schlagworte
Boswellia
Cytokines
Binding Sites
Arthritis
Tumor
Zeitschrift für Phytotherapie
