The +1059G/C polymorphism in the CRP gene is associated with decreased serum CRP levels and involvement of the terminal ileum in patients with Crohn's disease
D Thalmaier, J Dambacher, J Seiderer, A Konrad, V Schachinger, S Pfennig, JM Otte, A Crispin, B Göke, T Ochsenkühn, P Lohse, S Brand · Zeitschrift für Gastroenterologie · 2006 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background/Aims: Recently, a single nucleotide polymorphism in the CRP gene (1059G/C) has been reported. Our aim was to analyze the influence of this CRP polymorphism on the susceptibility and phenotype of Crohn's disease (CD). Methods: Using restriction fragment length polymorphism analysis, genomic DNA from 241 patients with CD and from 199 unrelated controls was analyzed for the +1059G/C substitution in the CRP gene and the three common CARD15 variants (R702W, G908R, L1007fsinsC). Serum CRP concentrations were measured using a latex based high-sensitivity immunoassay. Results: Homozygous C/C carriers were det…
