The novel Lambda-interferons IL-28A and IL-29 inhibit HCV replication in vitro and hepatic IL-28 mRNA expression is increased in HCV and CMV infection in vivo
F Beigel, J Dambacher, K Zitzmann, M Storr, T Olszak, B Goeke, CJ Auernhammer, A Kaul, R Bartenschlager, H Diepolder, S Brand · Zeitschrift für Gastroenterologie · 2006 · Heft 10
Bibliografische Angaben
Zusammenfassung
Introduction: IL-28A and IL-29 belong to a novel group of interferons named interferon (IFN)-lambdas. Recently, we demonstrated antiviral properties for these cytokines in intestinal epithelial cells (Am J Physiol Gastrointest Liver Physiol 2005; 289:G960–8). Aims/Methods: The aim of this study was to analyze receptor expression, signal transduction and antiviral functions, particularly against hepatitis C virus (HCV) infection, mediated by IL-28A and IL-29 in hepatic cells. The mRNA expression of IL-10R2 and IL-28R1, the receptor subunits required for IL-28A and IL-29 signaling, was determined by RT-PCR in hepa…
