Changes of [18F]FDG-uptake in hypoxic areas after single dose irradiation in FaDu hSCC xenografts
K Brüchner, F Hofheinz, R Bergmann, A Yaromina, F Hessel, J van den Hoff, M Baumann, B Beuthien-Baumann · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2008 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: [18F]2-fluoro-2-deoxy-glucose ([18F]FDG) is a glucose analog and is well established in diagnosis of tumours and treatment response. It was demonstrated a high degree of heterogeneity in inter-tumoural and intra-tumoural [18F]FDG uptake. We could show that [18F]FDG-uptake in unirradiated FaDu xenografts was significantly higher in hypoxic tumour areas in comparison to normoxic cells. The aim of this study was to investigate the influence of single dose irradiation on [18F]FDG-uptake in relation to hypoxia using autoradiography and quantitative histology. Material and Methods: 32 human FaDu squamous…