Multi-modal non-invasive imaging techniques show improved vector-distribution of HSV-EBV-RV hybrid vectors within experimental glioma
A Winkeler, R.T Ullrich, Y Waerzeggers, M Sena-Esteves, H Li, B Neumaier, P Monfared, S Vollmar, J Seehafer, M Hoehn, A.H Jacobs · Aktuelle Neurologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
One of the main problems in gene therapy of malignant gliomas is limited vector distribution within the target tissue. To serve a more wide-spread distribution of vector-mediated gene expression throughout the tumour glioma cells can be converted to vector producer cells onsite. Conversion of tumour cells to retrovirus packaging cells has been achieved using HSV-1/EBV/RV (HER) hybrid amplicons bearing retrovirus vector sequences and retroviral gag, pol and env genes1. A HER vector (HER-LITG) has been constructed containing the optical imaging (OI) gene firefly luciferase (luc, L), the positron emission tomograph…
