Glioma proliferation as assessed by FLT-PET in patients with newly diagnosed high grade glioma
R.T Ullrich, H Backes, H Li, L Kracht, H Miletic, K Kesper, B Neumaier, W.D Heiss, K Wienhard, A.H Jacobs · Aktuelle Neurologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
The aim of this study was to investigate the relationship between the in vivo derived kinetic parameters of 3((prime))-deoxy-3((prime))-18F-fluorothymidine (18F-FLT) and the proliferation rate measured in vitro by Ki-67 staining in patients with newly diagnosed high-grade gliomas. Thirteen patients with newly diagnosed high grade gliomas were investigated with 18F-FLT and methyl-11C-L-methionine (11C-MET) positron emission tomography (PET) and T1-, Gd-T1 and T2-weighted MRI on consecutive days. Tracer kinetic parameters of 18F-FLT as well as the standardized uptake value (SUV) and the tumor-to-background (T/B) r…
