PPAR gamma ablation in CD4+ T-cells augments T-cell responses in vivo and facilitates disease induction in experimental autoimmune encephalomyelitis

The peroxisome proliferator-activated receptor gamma (PPARg) belongs to a group of ligand-activated transcription factors involved in the regulation of metabolism and inflammation. PPARg is expressed in cells of the peripheral immune compartment like lymphocytes and dendritic cells, but also within the CNS, mainly in microglial cells and in neurons. Interestingly, oral administration of PPARg agonists ameliorates the clinical course and histopathological features in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. However, it is still unclear which cell type is primarily i…