The EMSA-SG natural history study: disease progression and survival

Objective: To study the natural history of MSA and prospectively assess disease progression using validated clinical scales. Aims: MSA is a sporadic neurodegenerative disorder characterised by parkinsonism, cerebellar ataxia, and dysautonomia. Progression is rapid and is steadily leading to death. Methods: A total of 144 patients were included at 15 EMSA-SG centres. Patients were followed up for two years with a complete neurological investigation every six months. Disease progression was assessed using the unified MSA rating scale (UMSARS). For survival analysis, vital status was assessed again 15 months follow…