A BFIS-like syndrome with late onset and febrile seizures: suggestive linkage to chromosome 16p11.2–16q12.1

Benign familial infantile seizures (BFIS) is a dominant idiopathic epilepsy with partial and secondary generalized seizures with age of onset between 3 and 12 months. Here we describe a four generation family with some characteristic features of BFIS in 8 affected members with an unusual clinical phenotype. Onset was consistently between 14 and 20 months of age with clusters of complex-partial or generalized tonic-clonic seizures and a high rate of febrile seizures, which have not been described for BFIS previously. All affected members showed multifocal interictal epileptiform discharges in the EEG. The known l…