CareLit Fachartikel

The effect of the Aurora-kinase inhibitor AZD1152-HQPA on primary ovarian cancer cell culture specimens

C Schem, CB Maas, K Bräutigam, DO Bauerschlag, N Arnold, J Weimer · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
1041845
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
C Schem, CB Maas, K Bräutigam, DO Bauerschlag, N Arnold, J Weimer
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088845

Zusammenfassung

Objective: Aurora kinases (Aurk) are involved in organizing the mitotic spindle apparatus, monitoring the correct chromosome segregation and are required for the process of cytokinesis. In many cancer entities including breast and ovarian cancer, AurkA and AurkB are overexpressed. AZD1152-HQPA is an aurora kinase inhibitor with enhanced selectivity for aurora B, causing a failure of chromosome segregation, followed by DNA endoreduplication and cell death. The post-operative treatment of ovarian cancer usually includes the application of the mitotic inhibitors Paclitaxel or Docetaxel that cause mitotic arrest. Me…

Schlagworte

Aurora-kinase ovarian cancer taxan Chromosome Segregation Tumor Aurora Kinases Ascites Breast Work AURKA Geburtshilfe und Frauenheilkunde