CareLit Fachartikel
Companion of a FISH-Test and PAP-staining to detect precancerous lesion of the cervix
Z Xie, K Maass-Poppenhusen, J Rudolph, N Maass, N Arnold, J Weimer · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Dokument
1041847
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Zusammenfassung
Objective: Cervical cancers almost invariably carry extra copies of chromosome arm 3q and 8q, resulting in gains of hTERC and C-MYC. Both genes are involved in carcinogenesis. Cervical precancerous lesions are characterized routinely by cytological tests of PAP smears, without consideration of the genetic cell conditions. It is aim of this study to settle the following questions: 1) Does FISH on PAP stained smears allow a comparison of cell neoplasm and genetic status? 2) Does this complement the conventional PAP diagnoses and prognoses? Material: We use interphase FISH with a triple-colour probe panel (Kreatech…
Schlagworte
Cervix
FISH
PAP
Smears
Cervical
Hterc
C-Myc
Normal
Lesions
Genetic
Morphologic
Cells
Precancerous
Chromosome
Gains
Geburtshilfe und Frauenheilkunde
