CareLit Fachartikel
Non-Invasive Imaging of Oncolytic Virotherapy by Genetic Capsid Labeling – Dynamic Monitoring of Virotherapy
J Jung, H Creutz, MJ Mathis, P Mallmann, RK Schmutzler, MA Stoff-Khalili · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Dokument
1041861
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Conditionally replicative adenoviruses represent a promising strategy to address the limited efficacy and safety issues associated with conventional cancer treatment. Despite rapid translation into human clinical trials and demonstrated safety, the fundamental properties of oncolytic adenovirus replication, spread and host-vector interactions in vivo have not been completely evaluated. Methods: We developed a noninvasive dynamic monitoring system to detect adenovirus replication. We constructed capsid-labeled E1/E3-deleted, wild-type adenoviruses and a conditionally replicative adenovirus by fusing the min…
Schlagworte
Imaging
Virotherapy
Breast Cancer
Oncolysis
Address
Geburtshilfe und Frauenheilkunde
