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Novel protective markers for ulcerative colitis in the IL2/IL21 region suggest a common genetic background for ulcerative colitis and celiac disease

J Glas, M Wetzke, D Roeske, S Pfennig, W Klein, JT Epplen, T Griga, U Schiemann, B Göke, T Ochsenkühn, M Folwaczny, B Müller-Myhsok, S Brand · Zeitschrift für Gastroenterologie · 2008 · Heft 09

Dokument
1041901
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
J Glas, M Wetzke, D Roeske, S Pfennig, W Klein, JT Epplen, T Griga, U Schiemann, B Göke, T Ochsenkühn, M Folwaczny, B Müller-Myhsok, S Brand
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-17 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0028-1089415

Zusammenfassung

Background/Aim: To analyze whether recently identified genetic risk markers for celiac disease influence the susceptibility to inflammatory bowel disease (IBD), we tested five single nucleotide polymorphisms (SNPs) associated with celiac disease in the 4q27 region (rs6840978, rs6822844, rs12642902, rs13119723, rs13151961) and the coding SNP rs4833837=p.Cys78Cys within the IL21 gene for association with IBD in a large German IBD cohort. Methods: The six SNPs were genotyped in a total of 2948 Caucasian individuals comprising 1461 IBD patients (514 with ulcerative colitis, 947 with Crohn's disease) and 1487 healthy…

Schlagworte

Association Allele Population Zeitschrift für Gastroenterologie