CareLit Fachartikel

Stress-induced activation of TGF-β and activin A signaling in hepatocytes leads to early expression of connective tissue growth factor (CTGF/CCN2)

AM Gressner, B Lahme, M Siluschek, K Rehbein, OA Gressner · Zeitschrift für Gastroenterologie · 2008 · Heft 09

Dokument
1041902
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
AM Gressner, B Lahme, M Siluschek, K Rehbein, OA Gressner
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-17 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0028-1089425

Zusammenfassung

Introduction: CTGF, a member of the CCN-family of functionally pluripotent cysteine-rich proteins is a downstream modulator of TGF-β action. Its expression in hepatocytes (PC), recently shown by us, is stimulated by exogenous TGF-β, but up-regulated also spontaneously in complete TGF-β-free culture conditions (1). Aim of this study was to identify potential autocrine mechanisms for CTGF regulation in PC. Methods: In rat PC cultures CTGF expression was followed by Western blots, metabolic labelling, and CTGF-luciferase activity, (phospho-)Smads2/3 were recorded by Western blots, and intracellular activation of TG…

Schlagworte

Activin Antibodies Cysteine Connective Tissue Growth Factor Connective Tissue Zeitschrift für Gastroenterologie